Deficient vasodilator mechanisms, increased vascular stiffness, with unresolving inflammation leading to a prothrombotic state and senescence are features of endothelial dysfunction. Endothelial dysfunction is often the unrecognized link between apparently unconnected diseases. For instance, a person with chronic heart failure is at increased risk of dementia and also of cancer. Understanding how to maintain healthy endothelial function is one of the most important challenges for extending healthspan.
Endothelial dysfunction is linked to age, and driven by common cardiovascular risk factors; high blood pressure, diabetes, raised LDL cholesterol or triglycerides, smoking, lack of exercise, poor diet.
OPC cause vasodilatation, reduce inflammation and promote antithrombotic functions of the endothelium, and in patients with chronic heart failure OPC improve cardiovascular function; as shown by the decrease in diastolic blood pressure and reduction in NT-proBNP (a biomarker of heart stress).
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
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This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
Combination of low amounts of OTB with OPC were found to have synergistic and sustained effects on key aspects of endothelial function, which restore vasodilator mechanisms by suppressing endothelin-1 and promoting nitric oxide synthesis.
Specialized endothelial cells form the blood-brain barrier, which acts as a semipermeable interface between circulating blood and the surrounding brain tissue. Fifteen percent of the blood pumped with every heart beat goes to the brain. Maintaining brain vascular function is critical for brain health.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
This description is roughly 150 characters and roughly 30+ words. Describe the technology in brief but clear detail. Do not over elaborate.
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This paragraph is ~100 characters, 30 words, should describe more about Cambrian Biopharma
